Zindiq Zaynutdin Nabati  in his book “Sitarul mustaqim” p 161 entitled chapter about Aisha (r.a) with words:

فصل في أم الشرور

“Chapter in mother of evils”.

Ali ibn Ibraheem al-Qummi said in his commentary (vol 2, p 377):

قال علي بن ابراهيم في قوله (ضرب الله مثلا) ثم ضرب الله فيهما مثلا فقال: (ضرب الله مثلا للذين كفروا امرأة نوح وامرأة لوط كانتا تحت عبدين من عبادنا صالحين فخانتاهما) فقال والله ما عنى بقوله فخانتاهما إلا الفاحشة

“Then Allah gave as an example of two of them (Aisha and Hafsa) and said: “Allah sets forth an example to those who disbelieve the wife of Nuh and the wife of Lut: they were both under two of Our righteous servants, but they acted treacherously towards them”, and said: by Allah! It’s clear from His words that   treachery means nothing but licentiousness..”

Kashani narrated in his tafsir as-Safi (1/390), as if imam Sadiq said about death of prophet (sallalahu alaihi wa ala alihi wa sallam):

انهما سقتاه قبل الموت يعني الامرأتين.

They poisoned him before his death, it’s mean (those) two woman”.

We all aware about shia attitude towards Aisha and Hafsa, so there no need to be genius to understand whom does they mean.